Juxtaglomerular cell changes in dogs with antirenin titers.

• Increasing evidence has accumulated to support the juxtaglomerular cell rather than the proximal tubular cell as being the site of renin formation in the kidney. The determination of the site of renin is important to the elucidation of the mechanism of stimulation of the renin-angiotensin pressor system. Goormaghtigh^ first demonstrated changes in the juxtaglomerular cell which indicated a secretory function and this led him to hypothesize this cell as the source of renin. More recent microdissection and fluorescent antibody studies are in accord with Goorniaghtigh's findings.